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[1]汤吉海,郭海东,陈献,等.酯化、水解两步法合成苯甲醇的工艺优化[J].南京工业大学学报(自然科学版),2011,33(04):12-15.[doi:10.3969/j.issn.1671-7627.2011.04.003]
 TANG Jihai,GUO Haidong,CHEN Xian,et al.Optimization of two-step synthesis of benzyl alcohol by esterification and hydrolysis[J].Journal of NANJING TECH UNIVERSITY(NATURAL SCIENCE EDITION),2011,33(04):12-15.[doi:10.3969/j.issn.1671-7627.2011.04.003]
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酯化、水解两步法合成苯甲醇的工艺优化()
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《南京工业大学学报(自然科学版)》[ISSN:1671-7627/CN:32-1670/N]

卷:
33
期数:
2011年04期
页码:
12-15
栏目:
出版日期:
2011-07-20

文章信息/Info

Title:
Optimization of two-step synthesis of benzyl alcohol by esterification and hydrolysis
文章编号:
1671-7627(2011)04-0012-04
作者:
汤吉海郭海东陈献崔咪芬乔旭
南京工业大学 化学化工学院,江苏 南京210009
Author(s):
TANG Jihai GUO Haidong CHEN Xian CUI Mifen QIAO Xu
College of Chemistry and Chemical Engineering, Nanjing University of Technology, Nanjing 210009, China
关键词:
相转移催化苯甲醇氯化苄酯化水解
Keywords:
phase-transfer catalysis benzyl alcohol benzyl chloride esterification hydrolysis
分类号:
O624.5
DOI:
10.3969/j.issn.1671-7627.2011.04.003
文献标志码:
A
摘要:
以氯化苄和甲酸钠为原料,采用十六烷基三甲基溴化铵作为相转移催化剂,通过酯化和水解两步法合成苯甲醇。分别考察原料摩尔比、酯化反应温度、催化剂用量、初始水量等因素对酯化反应的影响以及水解反应温度、加碱方式、初始水量等因素对水解反应的影响。结果表明:适宜的氯化苄与甲酸钠摩尔比为1∶1,酯化反应温度为110~115 ℃,催化剂用量为2%(以氯化苄为基准),初始水量与氯化苄的体积比为1∶1;适宜的水解反应温度为100 ℃,加碱速率为5 mL/h,酯化液与水的体积比为1∶1。在最优工艺条件下,苯甲醇的收率可达98%。
Abstract:
Benzyl alcohol was synthesized by the esterification and hydrolysis of benzyl chloride and sodium formate with phase-transfer catalyst. The effects of the initial molar-ratio of benzyl chloride to sodium formate, the esterification temperature, the amount of the catalyst, and the volume-ratio of benzyl chloride to water on the esterification process; and the effects of hydrolysis temperature, the pattern of adding the alkali, and the initial amount of water on the hydrolysis process were investigated. Results showed that the suitable process parameters were as follows: molar ratio of benzyl chloride to sodium formate of 1∶1, esterification temperature of 110~115℃, amount of catalyst of 2% of benzyl chloride, volume ratio of benzyl chloride to water of 1∶1, hydrolysis temperature of 100℃, feeding rate of alkali of 5mL/h, and volume ratio of esterification liquid to water of 1∶1. Under the conditions, the yield of benzyl alcohol could reach 98%.

参考文献/References:

[1]范成有.香料及其应用[M].北京:化学工业出版社,1990. [2]Bryant D R,McKeon J E,Ream B C.Palladium-catalyzed synthesis of benzyl esters from methyl-benzenes[J].Journal of Organic Chemistry,1968,33(11):4123-4127. [3]赵地顺.相转移催化原理及应用[M].北京:化学工业出版社,2007. [4]李传兆,江浩,王秀绢,等.氯化苄水解合成苯甲醇反应过程研究[J].现代化工,1999,19(5):26-28. [5]Wang T T,Huang T C,Yeh M Y.Benzyl alcohol from phase transfer catalyzed weakly alkaline hydrolysis of benzyl chloride[J].Chemical Engineering Commumication,1990,92:139-151. [6]李树安,张珍明.间接法相转移催化水解氯化苄制备苯甲醇的研究[J].现代化工,1996,16(7):34-35. [7]李金志.相转移催化水解法制备苯甲醇的研究[J].化工矿物与加工,2000(12):8-9. [8]苏丽红,李红玫,邱平.相转移催化合成乙酸苄酯[J].化学工程师,2006(5):13-14.

相似文献/References:

[1]陈曦,王俊,韩越,等.超声辅助SiW12/SiO2催化合成乙酸苄酯及动力学[J].南京工业大学学报(自然科学版),2011,33(04):24.[doi:10.3969/j.issn.1671-7627.2011.04.006]
 CHEN Xi,WANG Jun,HAN Yue,et al.Ultrasound assisted heteropoly acid catalyst SiW12/SiO2 for synthesis of benzyl acetate and kinetics[J].Journal of NANJING TECH UNIVERSITY(NATURAL SCIENCE EDITION),2011,33(04):24.[doi:10.3969/j.issn.1671-7627.2011.04.006]

备注/Memo

备注/Memo:
收稿日期:2011-01-14
基金项目:江苏省青蓝工程资助项目;江苏省高校自然科学基础研究计划资助项目(08KJB530006)
作者简介:汤吉海(1974—),男,湖北江陵人,副教授,主要研究方向为绿色化工;乔旭(联系人),教授,E-mail:qct@njut.edu.cn.
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