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[1]丘宝增,胡静怡,汤吉海,等.部分析因实验设计优化α-氯代十二酸合成工艺[J].南京工业大学学报(自然科学版),2015,37(03):51-55.[doi:10.3969/j.issn.1671-7627.2015.03.010]
 QIU Baozeng,HU Jingyi,TANG Jihai,et al.Optimization of synthesis of α-chlorododecanoic acid by fractional factorial design[J].Journal of NANJING TECH UNIVERSITY(NATURAL SCIENCE EDITION),2015,37(03):51-55.[doi:10.3969/j.issn.1671-7627.2015.03.010]
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部分析因实验设计优化α-氯代十二酸合成工艺()
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《南京工业大学学报(自然科学版)》[ISSN:1671-7627/CN:32-1670/N]

卷:
37
期数:
2015年03期
页码:
51-55
栏目:
出版日期:
2015-05-30

文章信息/Info

Title:
Optimization of synthesis of α-chlorododecanoic acid by fractional factorial design
文章编号:
1671-7627(2015)03-0051-05
作者:
丘宝增1胡静怡2汤吉海1杨运2陈献1费兆阳1乔旭1崔咪芬1
1.南京工业大学 化学化工学院,江苏 南京 210009; 2.江苏省东泰精细化工有限责任公司,江苏 镇江 212132
Author(s):
QIU Baozeng1HU Jingyi2TANG Jihai1YANG Yun2CHEN Xian1FEI Zhaoyang1QIAO Xu1CUI Mifen1
1.College of Chemistry and Chemical Engineering,Nanjing Tech University,Nanjing 210009,China; 2.Jiangsu Dongtai Fine Chemical Co. Ltd.,Zhenjiang 212132,China
关键词:
十二酸 α-氯代十二酸 实验设计 部分析因 优化
Keywords:
dodecanoic acid α-chlorododecanoic acid experimental design fractional factorial design optimization
分类号:
TQ028.3
DOI:
10.3969/j.issn.1671-7627.2015.03.010
文献标志码:
A
摘要:
采用5因素2水平的部分析因实验设计对十二酸氯化合成α-氯代十二酸的工艺进行优化,方差分析反应温度、反应时间、催化剂用量、Cl2流量和O2流量及其交互作用的统计重要度。通过线性模型回归和响应曲面分析各因素对α-氯代十二酸收率的影响规律,获得浓硫酸催化合成α-氯代十二酸的最佳实验条件为:十二酸20 g,反应温度135 ℃,反应3 h,催化剂用量为10%,Cl2流量为100 mL/min,O2流量为50 mL/min。在最优条件下,α-氯代十二酸的收率为96.0%。
Abstract:
Synthesis process of α-chlorododecanoic acid(α-CDA)through chlorination of dodecanoic acid(DA)was investigated by the fractional factorial design(FFD)of 5 factors and 2 levels.Statistical importance of reaction temperature,reaction time,catalyst amount,O2 and Cl2 flow rates and their interaction was analyzed. The effect laws of every factor to the yield of α-CDA were obtained by linear regression model and analyzed through response surface. Results showed that the optimized DA chlorination conditions using concentrated sulfuric acid was as follows:DA mass of 20 g,reaction temperature of 135 ℃, reaction time of 3 h, m(catalyst):m(DA)of 0.1, Cl2 and O2 flow rates of 100 and 50 mL/min,respectively. Under these conditions,the yield of α-CDA reached 96.0%.

参考文献/References:

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相似文献/References:

[1]丘宝增,胡静怡,汤吉海,等.部分析因实验设计优化α-氯代十二酸[J].南京工业大学学报(自然科学版),2015,37(03):1.
 QIU Baozeng,HU Jingyi,TANG Jinghai,et al.Optimization of synthesis of α-chlorododecanoic acid by fractional factorial design[J].Journal of NANJING TECH UNIVERSITY(NATURAL SCIENCE EDITION),2015,37(03):1.

备注/Memo

备注/Memo:
收稿日期:2014-03-22
基金项目:江苏省科技支撑计划(BE2011021)
作者简介:丘宝增(1988—),男,福建龙岩人,硕士生,主要研究方向为有机氯化反应; 汤吉海(联系人),副教授,E-mail:jhtang@njtech.edu.cn.
引用本文:丘宝增,胡静怡,汤吉海,等.部分析因实验设计优化α-氯代十二酸合成工艺[J].南京工业大学学报:自然科学版,2015,37(3):51-55..
更新日期/Last Update: 2015-05-20