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[1]王俊超,徐婷,彭茹洁,等.响应面法优化川芎中欧当归内酯A的提取工艺[J].南京工业大学学报(自然科学版),2018,40(03):43-48.[doi:10.3969/j.issn.1671-7627.2018.03.008]
 WANG Junchao,XU Ting,PENG Rujie,et al.Optimization of extraction technology of Levistolide A from Ligusticum chuanxiong Hort. by response surface methodology[J].Journal of NANJING TECH UNIVERSITY(NATURAL SCIENCE EDITION),2018,40(03):43-48.[doi:10.3969/j.issn.1671-7627.2018.03.008]
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响应面法优化川芎中欧当归内酯A的提取工艺()
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《南京工业大学学报(自然科学版)》[ISSN:1671-7627/CN:32-1670/N]

卷:
40
期数:
2018年03期
页码:
43-48
栏目:
出版日期:
2018-05-20

文章信息/Info

Title:
Optimization of extraction technology of Levistolide A from Ligusticum chuanxiong Hort. by response surface methodology
文章编号:
1671-7627(2018)03-0043-06
作者:
王俊超1徐婷1彭茹洁1韩伟12
1.华东理工大学 中药现代化工程中心,上海 200237; 2.上海市中医临床重点实验室,上海 201203
Author(s):
WANG Junchao1XU Ting1PENG Rujie1HAN Wei12
1.Engineering Center for Traditional Chinese Medicine Moderniziation,East China University of Science and Technology, Shanghai 200237,China; 2.Shanghai Key Laboratory of Traditional Chinese Clinical Medicine,Shanghai 201203,China
关键词:
川芎 欧当归内酯A 超声辅助提取 响应面分析法
Keywords:
Ligusticum chuanxiong Hort. Levistolide A ultrasonic-assisted extraction response surface methodology
分类号:
R284.2
DOI:
10.3969/j.issn.1671-7627.2018.03.008
文献标志码:
A
摘要:
采用响应面分析法优化川芎中欧当归内酯A的超声辅助提取工艺。在单因素试验的基础上,以提取时间、液固比、提取温度为响应因子,欧当归内酯A质量分数为响应值,采用三因素三水平的响应面分析法优化,得到最佳工艺条件:液固比13 mL/g,提取温度40 ℃,提取时间62 min。在最佳工艺条件下,欧当归内酯A质量分数为0.525 mg/g,该值比《中国药典》所用方法的值提高48.7%。
Abstract:
The extraction technology of Levistolide A from Ligusticum chuanxiong Hort. was optimized by response surface methodology(RSM).The single factor test was conducted first,followed by the three factors and three levels response methodology.The ultrasonic extraction time,ratio of liquid to material and extraction temperature were chosen as the factors with the mass fraction of Levistolide A as response value.The optimum extraction conditions were as follows:ratio of liquid to material of 13 mL/g,extraction temperature of 40 ℃,and ultrasonic extraction time of 62 min.Under the optimum conditions,the mass fraction of Levistolide A was 0.525 mg/g with 48.65% higher than that by the method of the Chinese Pharmacopoeia.

参考文献/References:

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相似文献/References:

[1]徐婷,王俊超,赵少甫,等.川芎中欧当归内酯A的提取纯化与结构表征[J].南京工业大学学报(自然科学版),2018,40(02):71.[doi:10.3969/j.issn.1671-7627.2018.02.012]
 XU Ting,WANG Junchao,ZHAO Shaofu,et al.Preparation and determination of levistolide A from Ligusticum chuanxiong Hort.[J].Journal of NANJING TECH UNIVERSITY(NATURAL SCIENCE EDITION),2018,40(03):71.[doi:10.3969/j.issn.1671-7627.2018.02.012]

备注/Memo

备注/Memo:
收稿日期:2016-09-07
基金项目:上海市中医临床重点实验室开放课题(14DZ2273200)
作者简介:王俊超(1990—),男,河南许昌人,硕士,主要研究方向为天然产物的分离与纯化; 韩伟(联系人),教授,E-mail:whan@ecust.edu.cn.
引用本文:王俊超,徐婷,彭茹洁,等.响应面法优化川芎中欧当归内酯A的提取工艺[J].南京工业大学学报(自然科学版),2018,40(3):43-48..
更新日期/Last Update: 2018-05-31