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[1]朱桂琴,何伟,方正,等.微通道反应器中1-甲氧基-2-丙醇的连续合成[J].南京工业大学学报(自然科学版),2019,41(05):620-624.[doi:10.3969/j.issn.1671-7627.2019.05.012]
 ZHU Guiqin,HE Wei,FANG Zheng,et al.Continuous synthesis of 1-methoxy-2-propanol in a microchannel reactor[J].Journal of NANJING TECH UNIVERSITY(NATURAL SCIENCE EDITION),2019,41(05):620-624.[doi:10.3969/j.issn.1671-7627.2019.05.012]
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微通道反应器中1-甲氧基-2-丙醇的连续合成()
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《南京工业大学学报(自然科学版)》[ISSN:1671-7627/CN:32-1670/N]

卷:
41
期数:
2019年05期
页码:
620-624
栏目:
出版日期:
2019-10-22

文章信息/Info

Title:
Continuous synthesis of 1-methoxy-2-propanol in a microchannel reactor
文章编号:
1671-7627(2019)05-0620-05
作者:
朱桂琴何伟方正郭凯
南京工业大学 生物与制药工程学院,江苏 南京 211800
Author(s):
ZHU Guiqin HE Wei FANG Zheng GUO Kai
College of Biotechology and Pharmaceutical Engineering, Nanjing Tech University,Nanjing 211800, China
关键词:
微通道反应器 1-甲氧基-2-丙醇 连续合成
Keywords:
microchannel reator 1-methoxy-2-propanol continuous synthesis
分类号:
O624
DOI:
10.3969/j.issn.1671-7627.2019.05.012
文献标志码:
A
摘要:
在微通道反应器中,以甲醇和环氧丙烷为原料合成1-甲氧基-2-丙醇。考察尺度效应(管径和微反应器类型)对反应的影响并对反应条件(催化剂用量、反应物摩尔比、停留时间和反应温度)进行优化。结果表明:内径为0.5 mm、体积为10 mL的聚四氟乙烯毛细管及T形混合器能有效促进物料间混合; 甲醇与环氧丙烷在微通道反应器中的最优反应条件为催化剂用量0.5%、甲醇与环氧丙烷摩尔比3:1、120 ℃下反应7 min、压力2 MPa。在最优反应条件下,环氧丙烷转化率为99.4%,产率可高达99.1%。
Abstract:
1-methoxy-2-propanol was synthesized from methanol and propylene oxide in a microchannel reactor. The influence of scale effect(tube diameter and microreactor type)on the reaction was investigated and the reaction conditions(catalyst dosage, reactant molar ratio, residence time and reaction temperature)were optimized. Results showed that polytetrafluoroethylene capillary tube with diameter of 0.5 mm and volume of 10 mL, and T-type mixer could effectively promote the mixing between the materials. The optimal reaction conditions of methanol and propylene oxide in the microchannel reactor were catalyst dosage of 0.5%, ratio of methanol to propylene oxide of 3:1, temperature of 120 ℃, residence time of 7 min, and pressure of 2 MPa.Under the optimum conditions, the conversion of propylene oxide was 99.4%, and the yield was up to 99.1%.

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备注/Memo

备注/Memo:
收稿日期:2019-07-15
基金项目:国家自然科学基金(21776130)
作者简介:朱桂琴(1995—),女,E-mail:18260088608@njtech.edu.cn; 郭凯(联系人),教授,E-mail:kaiguo@njtech.edu.cn.
引用本文:朱桂琴,何伟,方正,等.微通道反应器中1-甲氧基-2-丙醇的连续合成[J].南京工业大学学报(自然科学版),2019,41(5):620-624..
更新日期/Last Update: 2019-09-30